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Benzodiazepine treatment method really should be discontinued without delay by a sluggish and gradual dose reduction routine.[17][seventy five] Tolerance develops towards the therapeutic consequences of benzodiazepines; as an example tolerance takes place for the anticonvulsant effects and Therefore benzodiazepines usually are not usually advisable for the extended-time period administration of epilepsy. Dose raises may possibly overcome the effects of tolerance, but tolerance may possibly then establish to the upper dose and adverse effects might raise.
Diazepam is stored preferentially in certain organs, including the heart. Absorption by any administered route and the risk of accumulation is drastically enhanced within the neonate, and withdrawal of diazepam in the course of pregnancy and breast feeding is clinically justified.[one hundred ten]
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